The rapper posted the bet on Instagram, with the wager giving him returns of $2.75million should Argentina triumph within 90 minutes at the Lusail Stadium.
The three-way bet poses an additional risk for Drake, with a draw a potential outcome at the end of the 90 minutes.
The Canadian has placed a series of mammoth bets on sporting events in recent months.
He lost over $2 million betting on former UFC champion Israel Adesanya to defend his title against Alex Pereira last month.
A previous football bet saw Drake place $649,000 on an accumulator featuring Barcelona to win El Clasico against Real Madrid and Arsenal to beat Leeds.
Arsenal recorded a 1-0 win over Leeds in the Premier League, but Barcelona were beaten 3-1 by Real Madrid.
Drake also wagered $230,000 on Charles Leclerc to win the Spanish Grand Prix this year, only for the Ferrari driver to suffer engine failure.
The ‘Drake curse’ has been repeatedly cited, with numerous teams and athletes losing an upcoming sporting event after coming into contact with the rapper.
Canada’s national team suffered a group stage exit in Qatar without winning a match, shortly after posing with Drake.
Conor McGregor suffered defeat in the UFC after being pictured with Drake, while Anthony Joshua was stunned by Andy Ruiz Jr in their first heavyweight world title fight in 2019.
The same year saw PSG suffer a 5-1 loss to Lille, Sergio Aguero miss a penalty against Tottenham in the Champions League and Jadon Sancho’s Borussia Dortmund fall to a 5-0 loss to Bayern Munich.
France heads into the final as narrow favorite and are seeking to retain the World Cup, after winning the tournament in 2018 in Russia.
But all eyes will be on Messi who, at 35, has one final chance to win the trophy that has evaded him throughout his career.